This was a fairly open subject. However, I didn't want to just take a shot of someone's hands while they do something interesting with them, so I decided to take a full shot of my model with the focus on her hands. 

I actually embarked on this project with the intention of a self portrait. This didn't go according to plan, as I shot fairly wide open (f1.4, 35mm) I had extreme difficulty composing the image AND getting my hand in focus. So I had to call in the big guns, my regular model, Sarah.

A bit of a rocker, she knew how to pose for this one. Also, explaining your vision to the model helps a lot! She also claims she is actually strumming a chord, but I couldn't tell you which one.

A softbox at the top left lit the scene well (I wanted the face in the dark so as not to steal focus) and a separate, bare flashgun just off to the left, pointed at the focussed hand.